Epps was born at Wishard Hospital in Indianapolis, IN. Epps' natural comedic ability was encouraged at an early age, and he began performing stand-up as a teenager. Epps moved to Atlanta where he worked at the Comedy Act Theater, before moving to Brooklyn to star in Def Comedy Jam in 1995. Epps ended up on the Def Comedy Jam tour and starred in two of HBO's Def Comedy Jam broadcasts.
Epps' first on screen appearance came in Vin Diesel's directorial debut, Strays in 1997.
In 1999, Epps was then cast as Ice Cube's co-star (effectively, Chris Tucker's replacement) in the sequel, Next Friday. This came after weeks of auditions after Ice Cube attended a stand-up set Epps did, and then asked Epps to try out for the part of Day-Day Jones. His role as Day-Day Jones was a breakthrough for the new actor, who was already familiar to much of the audience from his stand-up work. Later that year, Epps had a cameo in 3 Strikes, and supported Jamie Foxx in Bait.
Epps' name has become synonymous with a particular style of humor, through his appearance with several other African-American artists in the same genre. Aside from featuring Cube, the common thread of these films was the hilarious prominence of marijuana-smoking comic characters, like the ones portrayed by Epps.
Epps most recently starred alongside Jordin Sparks and Whitney Houston in the 2012 remake of Sparkle, in his first non-comedic role as the main antagonist, Satin. A stand-up comic by day, an evil and abusive drug kingpin by night in engaged in an affair with the titular character's sister, Sister.
Epps also has a song called Big Girls, which came out in 2008. It was originally recorded by Bow Wow, and featuring Yung Joc. The song is currently on iTunes and can be found on his album,Funny Bidness - Da Album, which was released October 27, 2009. Epps also has featured in rapper French Montana's 'Mac wit da Cheese' mixtape which was released April 19, 2009.
Epps is also featured on the Dom Kennedy song "Intro/Hard Work" on his Best After Bobby mixtape.
Epps served as the "Super Bowl ambassador" in his native Indianapolis for the 2012 Super Bowl. He was featured in commercials promoting the Super Bowl Village and he made special appearances in the Village during the week of the Super Bowl.